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A new study by Czech scientists found that residents living in the smog-laden city of Ostrava, Czech Republic, are more resistant to air pollution. The researchers found that the Ostrava people’s genes were more capable of repairing DNA damage caused by air pollution than the genes of the residents of the capital Prague, and thus built a stronger barrier for the host to resist air pollution.
Due to the presence of a large number of steel mills, Ostrava, the third largest city in the Czech Republic, has become one of the most polluted cities in Europe
Although scientists believe that the activities of many genes in Ostrava vary from others, in the course of the study they focused on a gene called XRCC5. Ostrava is the third largest city in the Czech Republic and has a population of more than 300,000. Due to the presence of a large number of steel mills, Ostrava has become one of the cities with the most serious air pollution in Europe, and the pollution level has sometimes reached four times the allowable limit of the EU. If the level of pollution continues to remain high, the Ostrava government can only force heavy industry to cut production.
This new discovery also raises the question of how the body can quickly adapt to the surrounding environment. In general, human evolution takes thousands of years, but studies of Ostrava genes show that in some cases this evolution takes only a short time. 150 years ago, Ostrava became an industrial city, that is to say, the change of local people's genetic activity was only a matter of decades.
This new study was conducted by the Institute of Experimental Medicine in Prague. Dr. Pavel Rosner of the Institute of Genetics, said that XRCC5 is responsible for repairing DNA damage. In an interview, he said: "If an organism is exposed to a contaminated environment, certain identified substances in the contamination will damage the DNA due to metabolism, resulting in mutations and mutations. The Ostrava people have a higher level of XRCC5 gene expression. Compared with Prague residents, they are also more capable of repairing DNA damage."
Dr. Rossner pointed out that this study demonstrated for the first time that XRCC5 can repair DNA damage caused by air pollution. In addition, this study also found that other genes also follow the footsteps of XRCC5 and are more active in combating the harmful effects of air pollution. After studying the DNA damage that occurred at the police in Ostrava, Rosner and his team began to study the repair of genes. A study of the Ostrawa police found that although the city's pollution level is far higher than in Prague, their level of DNA damage is comparable to that of their counterparts in Prague.
Although the new study found that urban residents suffering from air pollution saw hope, Rosner cautioned that people must not be overly optimistic. The study only involved 60 volunteers from Ostrava and Prague, and none of the participants had a sample of a certain size as the basis. The findings may be “paradoxicalâ€. But he also pointed out that they are conducting more in-depth and extensive research to confirm this finding.
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